glutathione reducible linker Versatile Click Enabling Native Peptide Release from Nanocarriers upon Redox Trigger Linkers: An Assurance for Controlled

81627901), the National Natural Science Foundation of China (Grant Nos

Glutathione is essential for: Supporting liver detoxification pathways Binding to heavy metals and environmental toxins Helping eliminate harmful compounds through proper channels 3

To visualize small-molecule metabolites localized within TLS, we used matrix-assisted laser desorption/ionization time of flight imaging mass spectrometry and found significant accumulation of glutathione (reduced form: glutathione [GSH], oxidized form: glutathione disulfide [GSSG]) within TLS (Figure 1C)

Targeting OGG1 arrests cancer cell proliferation by inducing replication stress