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3,3-Diindolylmethane and indole-3-carbinol: Potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signalling pathways

Transcriptomic adaptation and gene regulatory network rewiring Distinct drug-tolerant transcriptional states were identified by using scRNA-seq on malignant cells isolated from a cohort of BRAF mutant melanoma patient-derived xenografts (PDXs) subjected to concurrent RAF and MEK inhibition 43