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Both GshF - and mito-GshF expression prevented BSO-induced cell death up to millimolar amounts of drug treatment in a panel of human and mouse cell lines (Fig

The growing understanding of AD as a multifactorial disease necessitates an approach that simultaneously addresses tau pathology, neuroinflammation, oxidative stress, mitochondrial dysfunction, and synaptic loss ( 4.2 The role of neuroinflammation in AD pathogenesis Recent evidence underscores neuroinflammation as a central player in AD progression

This led to the discovery of NP-BTA, a N-pyridinyl--thienyl-acrylamide derivative, was discovered to inhibit the essential enzyme glutaminyl-tRNA synthetase (Gln4), representing a novel antifungal mechanism of action (Fu et al., 2021)