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Mahboob, A

In particular, fibrosarcoma, a typical tumor with a little-known relationship with the ovary, can increase plasma CXCL10, which reaches the ovaries, binds to IL18R1 on the ovaries, and triggers multiple downstream ovary-disrupting signals

BRAF inhibitor-induced MAPK suppression triggers paradoxical ECM remodeling via mesenchymal dedifferentiation programs, activating YAP/MRTF mechanosensors that sustain tumor survival through actin cytoskeleton reorganization

Conclusions Our findings suggest that high levels of Hb and heme can be used to mark neovasculogenesis in herniated nucleus pulposus, which further promotes nucleus pulposus degeneration through heme iron-dependent cell death