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Consequently, this experiment confirmed that dopamine depletion does not abolish the ability of D2R-DAT disruption to promote dopamine-driven behavior

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The hypothalamic projection involves noradrenergic neurons of the locus coeruleus (LC) and serotoninergic neurons of the dorsal and median raphe nuclei (DR), which pass through the lateral hypothalamus and reach axons of the histaminergic tubero-mamillary nucleus (TMN), together forming a pathway extending into the forebrain, cortex and hippocampus

Cytosolic cysteine comes from only three sources: (1) from methionine via the methionine cycle and the transsulfuration pathway, (2) direct import into the cell from the plasma, and (3) from excess protein catabolism over protein synthesis