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Mitochondrial fission is promoted by the activation and translocation of dynamin-related protein 1, whereas mitochondrial fusion is mediated by optic atrophy 1, whose function may be disrupted by proteolytic cleavage, OPA1 is repressed by proteolysis, leading to dysregulation of mitochondrial fusion

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To further characterize caffeine-alcohol interaction, we focused our research on the potential ability of caffeine to affect the neurophysiological and neurochemical processes underlying the reinforcing properties of alcohol