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It remains to be elucidated to which extent and under which conditions the ectoenzymedependent (Figure 1) and independent pathways may contribute to the supply of cysteine for the GSH synthesis in neurons under physiological or pathological conditions

The selective ULK1/2 inhibitor, DCC-3116, synergizes with the KRASG12C inhibitor sotorasib to suppress KRAS-driven LC, whereas this combination has been assessed only in early preclinical stages and lacks predictive biomarkers for patient stratification (17)

Effects of encapsulated methionine on skeletal muscle growth and development and subsequent feedlot performance and carcass characteristics in beef steers