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Correspondingly, the inhibition of NF-B by BAY 11-7082 significantly increased the survived SGN numbers, while decreased the C-CASP3 positive SGN numbers and the C-CASP3 expression in peroxynitrite + BAY 11-7082 group compared with the peroxynitrite group (Figures 9DF)

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TCGA data analysis The cBioportal for Cancer Genomics (www.cbioportal.org) was used to analyse the relationship between p53 protein expression and SLC7A11 or NQO1 mRNA expression across all available RPPA and RNAseq datasets

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Immunocytochemistry Astrocytes on coverslips were fixed in 4% paraformaldehyde (FUJIFILM Wako) for 15 min at room temperature

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