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Obstet Gynecol 2010;116:223-236 Laufer MR

Circadian Rhythm Disruption in Triple-Negative Breast Cancer: Molecular Insights and Treatment Strategies

Why the Eye Area Ages First and Fastest The periocular area the skin surrounding the eyes has unique characteristics that make it the most challenging and most visible area of facial aging: Thinnest skin on the face: At just 0.5mm, the periocular dermis has minimal collagen and elastin reserve losses that would be invisible in thicker facial skin are immediately visible here Virtually no sebaceous glands: The eye area produces almost no natural oil making it chronically dry without active hydration support, and causing fine dehydration lines to appear rapidly Constant muscular contraction: The orbicularis oculi muscle contracts thousands of times daily through blinking, squinting, smiling, and expressions mechanically creasing the overlying skin repeatedly