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Paik PK, Pillai RN, Lathan CS, Velasco SA, Papadimitrakopoulou V

Administration of 21-aminosteroid attenuated post-CCI lipid peroxide accumulation and increased basal and maximal ETC activity as well as ETC/ATP synthase uncoupling [84]

Although it has been demonstrated that Epitalon exerts, among other effects, a direct influence on melatonin synthesis, alters the mRNA levels of interleukin-2, modulates the mitogenic activity of murine thymocytes, and enhances the activity of various enzymes, including AChE, BuChE, and telomerase, it remains uncertain whether these are the sole mechanisms of action of this compound

More rigorous clinical studies and higher-quality evidence are needed to establish the strength and cause-and-effect relationship of this correlation