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Tryptophan breakdown pathway in bipolar mania

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Saudi J Biol Sci 28(1):917927 Strup AE, Hjorthj C, Jensen HD, Melau M, Davy JW, Nordentoft M, Albert N (2023) Self-reported reasons for discontinuation or continuation of antipsychotic medication in individuals with first-episode schizophrenia

Moreover, the COVID-19 condition is associated with increased GCPII expression in astrocytes [28, 192] and a shift in tryptophan metabolism toward the kynurenine pathway (Boldrini et al ., 2021), resulting in altered mGluR3 and NMDA receptor signalling [28]