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It was previously shown that IL-6 plays a pivotal role in muscle wasting mechanisms (Belizario et al., 2016), although we could not observe evidence of atrophy in neither SOL nor EDL in our previous results (Andrich et al., 2018b)

Therefore, blocking the formation of DTCs or targeting DTCs for treatment is expected to reduce the number of stable drug-resistant cells by lowering the formation of stable drug-resistant cells, which can thus improve the therapeutic outcome of tumours

Tan HK, Yates E, Lilly K, Dhanda AD

Compared with patients without lung involvement, the occurrence of lung metastasis significantly reduces the survival of patients and increases the risk of death