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Furthermore, mRNA levels of NAD(P)H quinone oxidoreductase 1 (Nqo1) and haem oxygenase 1 (Hmox1), which are known targets of Nrf2 (Nfe2 like bZIP transcription factor 2), were downregulated in the liver of aspartame-exposed mice compared with the control group (Finamor et al., 2021)

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These are usually transient and dose-dependent

That said, some people do find yohimbine to be mildly stimulating, which is why we recommend taking it first thing in the morning (mostly so it doesnt interfere with your sleep)