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At the same time, it preserved the homeostasis of CD8+ splenocytes, maintaining their cytotoxic function without provoking an excessive inflammatory response [50], suggesting Epitalons role in recalibrating, rather than overactivating, immune function

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So, if you are frequently stressed out or are constantly dwelling on the source of your stress, you could have abnormally high levels of cortisol which in turn causes high levels of leptin