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To reduce severe facial pain attacks when medications (like carbamazepine or gabapentin) do not work well or cause too many side effects

Ketamine was initially introduced as an anesthetic and analgesic for medical applications ( 5.1 Pharmacological effects 5.1.1 NMDAR antagonism Ketamine exerts its primary effects by acting as a noncompetitive antagonist of NMDARs and reducing glutamate-mediated excitatory neurotransmission (Zhou and Tajima, 2023)