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As a core metabolic product, lactate may promote the release of inflammatory mediators (e.g., IL-6, TNF-) by activating the TGF- signaling pathway, while enhancing NF-B pathway activity to exacerbate local inflammatory infiltration in lung tissue but this direct activation has not been demonstrated in COPD airway cells

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To avoid maternal T cell activation against fetal antigens, trophoblasts regulate T cell function by expressing indoleamine 2, 3 dioxygenases (IDO), an enzyme that inhibits T cell proliferation by depleting tryptophan (6668)

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