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Aloe emodin exerts potent anticancer effects in MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cell lines through activation of both apoptotic and autophagic pathways, sub-G1 cell cycle arrest and disruption of mitochondrial membrane potential (m)

Nat Cell Biol 2010

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Introduction Cell death is widely identified as a pivotal partaker in mammalian development, homeostasis regulation, and a variety of diseases, which also has an intimate association with other physiological processes ( Non-alcoholic fatty liver disease is a chronic metabolic liver disease without other secondary causes or excessive alcohol consumption, which consists of a constellation of liver disorders, including simple steatosis and non-alcoholic steatohepatitis (NASH) ( Considering the prevalence of NAFLD and its detrimental effects on human health, it is urgent to seek effective therapeutic methods for the disease