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However, many studies have emphasized the preventive and therapeutic approaches of antioxidants for patients with DE (Table 4 and Table 5)

Acknowledgements We thank Professor Qianfei Wang (Beijing Institute of genomics, Chinese Academy of Sciences) and Professor Qianben Wang (Department of Pathology, Duke University School of Medicine, Durham, USA) for critical comments and advice on the manuscript

Though classically known to participate in the reduction of a broad spectrum of carbonyl-containing substrates including prostaglandins, steroids, and xenobiotics in phase 1 detoxification, a report in 2008 by Bateman et al

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