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For instance, TMAO, a metabolite produced by gut bacteria from dietary choline and carnitine, is closely associated with adverse cardiovascular outcomes when its plasma levels are elevated ( Shigella , can promote systemic inflammation, thereby increasing the risk of CVD ( Given the complex interactions between the gut microbiota and drugs, as well as the influence of the gut microbiota on CVD, the gut microbiota also plays a crucial role in shaping the therapeutic effects and side effects of cardiovascular drugs

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