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Investigating the response of the butyrate production potential to major fibers in dietary intervention studies

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We hypothesize that the influence of SFN on the gut microbiota is at least partly related to the effects on their habitat, i.e., the gut such as (i) alleviation of oxidative stress and inflammation in the intestine, (ii) increase of the expression of tight junction proteins, preventing excessive intestinal permeability and invasion of luminal bacteria, and (iii) promotion of gut detoxification capability via increase of activity of phase II detoxification enzymes such as GSTs

Preclinical research has demonstrated that IL-10 deficiency exacerbates hepatic inflammation and hepatocellular injury in mice, while stimulating IL-10 production in HSCs and KCs can prevent alcohol-induced liver damage [161, 162]