bpc 157 clinical evidence safety Multifunctionality and Possible Medical Application of the Peptide—Literature and Patent Review The Hidden Risks of BPC‑157:

This group may have an elevated risk of consuming excess amounts of vitamin B12, particularly if there are misunderstandings about proper dosage

doi: 10.1001/jamadermatol.2014.3324 45 AcharyaPMathurM

However, some people experience frequent urination, nausea, vomiting, fatigue, headaches, and muscle weakness

While the IOM had based B12 needs on the amount required to correct hematological parameters for people with pernicious anemia, the EFSA had almost 20 more years of research to draw on, and concluded that the most suitable approach was basing needs on biomarkers (serum B12, holotranscobalamin, MMA, and homocysteine)