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Conditional deletion of NFKB2 and/or RelB (in both total T cells and Tregs) has revealed a critical role for NFKB2 in maintaining Treg homeostasis (135)

One consideration that partially offsets the bioavailability difference involves absorption kinetics

Additionally, co-infection, such as with viral hepatitis, is common among the HIV-infected population and is known to decrease life expectancy (Sulkowski, 2008)