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Trends Cancer (2020) 6(5):38091

147 published a randomized trial in which the melatonin/hypothermia group, at 5 days of life, had fewer seizures and fewer white matter abnormalities on MRI

Curcumin may also increase the activity of phase II detoxification enzymes, such as GSTs and quinone reductase (QR) (see also Nrf2-dependent antioxidant pathway) (35, 38, 39)

ROS can activate Toll-like receptor (TLRs) and peroxisome proliferator-activated receptors- (PPAR-), and microglia are sensitive to signals from TLRs and PPAR- (Kim et al., 2015b), triggering a series of inflammatory responses in turn