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These receptors can also assemble inflammasome complexes, such as NLR family pyrin domain containing 3 (NLRP3), in coordination with absent in melanoma 2 (AIM2), resulting in the release of pro-inflammatory cytokinesincluding interleukin-1 (IL-1), IL-18, and TNF-and thereby amplifying neuroinflammation (Harms et al., 2021

Other research suggests something different - moderate amounts (201-325 mg daily, like 2-3 cups of coffee) might increase testosterone, but larger amounts can decrease it [23]