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Macrophages might be the main reason for the increased expression of CD38 and decrease of NAD related to aging in aging tissues

Bellavia A, Centorrino F, Jackson JW, Fitzmaurice G, Valeri L

Moreover, they showed that sesamol prevented gut barrier damage by enhancing the expression of tight junction proteins (occludin, claudin-1, and ZO-1), recovering the loss of gut mucus layer while increasing SCFAs through changes in the gut microbiome structure by enhancing the relative abundance of Coprococcuscus, Butyricicoccus, Odoribacter, and AF12 [470]