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Because RB1 is a major downstream effector of CDK4/6 signaling, RB1 loss in cancer cells contributes intrinsic resistance to CDK4/6i 1,10,11,12,13,14

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For the understanding of neuropsychiatric disorders, it is important to know that neurogenesis in the cortex is a prenatal process, while gliogenesis happens both prenatally and after birth