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Description

Targeted delivery of probiotics and their metabolites, based on the pathological link between intestinal microbiota metabolites and ferroptosis, may help inhibit ferroptosis, correct microbiota dysregulation, and restore immune homeostasis, offering a promising precision intervention strategy to alleviate IBD inflammation

In other words, ferroptosis sensitivity is controlled by several metabolic and biochemical pathways and processes, including cysteine metabolism, glutathione metabolism and radical homeostasis (Figure 1)