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N Engl J Med 1988;318:17208

Nature, 508(7495), 258262

Several large-scale population studies have identified an association between unexplained high B12 and the subsequent diagnosis of solid tumors

However, due to the lack of specificity of many chemotherapeutic drugs for cancer cells, they can also kill healthy cells that are in rapid proliferation phase while killing cancer cells, which may lead to serious side effects