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Because immune-related adverse events were identified through chart review, the evaluation might have been limited by inconsistent documentation of chart notes, such as the underreporting of patient symptoms

Several studies have reported that supplementing rats with both L-carnitine and alpha-lipoic acid halts age-related increases in reactive oxygen species (ROS), lipid peroxidation, protein carbonylation, and DNA strand breaks in heart, skeletal muscle and brain, concomitant with improvement in mitochondrial enzyme and respiratory chain activities [146149]

Ohsaki, Y., Cheng, J., Suzuki, M., Fujita, A