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All authors: Katherine M

Previous studies have found that the mechanism of ROS-induced barrier dysfunction in endothelium is by destroying TJs the same as that in epithelial cells (Rao, 2008)

Additionally, established drugs like 5-amino salicylic acid, that alters mitochondrial metabolism 174 , might already be efficient by targeting epithelial metabolism

In addition, some bioengineered skin substitutes such as Dermagraft and Apligraf have been developed to accelerate the healing of venous ulcers (Nicholas 2016