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the co-titration is why the combination is not something to improvise

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Drug deposition can irritate or even damage the delicate nasal mucosa, particularly with frequent use, preservatives, or permeation enhancers, and improper device contact can traumatise the septum (Chung et al., 2023

Purification and Scale-Up Considerations After synthesis with various precursors, the yield contains impure CQDs with the presence of by-products, unreacted precursors, and impurities which might interfere with the characterisation, potentially leading to experimental error [79]