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It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys

Cell-extracellular matrix interactions in normal and diseased skin

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2.2 CRISPR-Cas9 mediated generation of VeroS KO cell lines VeroS cells have a significantly higher transfection efficiency than Vero cells and were therefore chosen to produce the knockout cell lines