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Quercetin undergoes the first-pass effect, i.e., quercetin is metabolized in the liver once it is entered into our body due to its poor absorption in the gastrointestinal tract since it is surrounded by a mucus layer with 90% water content, and it undergoes the first-pass effect (gastrointestinal instability) (Date et al., 2011

Guo M, Ying Y, Chen Y, Miao X, Yu Z

Spicer JD, Shewale JB, Antonoff MB, Correa AM, Hofstetter WB, Rice DC, Vaporciyan AA, Mehran RJ, Walsh GL, Roth JA, Swisher SG , Sepesi B

Mutants selected with pyrimethamine (input 2) were then used to co-infect mice with a WT parasite line that constitutively expressed Cas9 under an hsp70 promoter ( cas9 )