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Likewise, a greater concentration of the compound (40mg/kg once per day during 14 days) drove to greater improvements when compared to middle doses (20mg/kg day) and low doses (10 mg/day) A ferulic acid derivate designed as C1a (ferulic acid conjugated with octopamine) was shown to effectively alleviates clinical signs and inflammatory mediators in vitro and in vivo models of IBD, showing even greater benefits that ferulic acid alone at the same doses (1 or 5 mg/kg per day during 14 days) [384]