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During the last years, the utilization of patient stem cellbased high-throughput screening approaches and in silico prediction tools such as network mapping, genome-wide association studies, (GWAS) and rare variant association studies (RVAS) significantly accelerated the identification of candidate drugs for disease treatment

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In humans, alterations in the normal functioning of these efflux pumps are implicated in the etiology of diseases such as DubinJohnson syndrome 7 and cystic fibrosis 8,9,10