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Alpha lipoic acid (ALA) is a natural substance found in some foods and is also synthesized in the body

Table 2: Changes from Baseline to Week 26 in Visceral Adipose Tissue (cm 2 ) by Treatment Group (Intent-To-Treat Population with Last Observation Carried Forward) Table 3: Changes from Baseline to Week 26 in IGF-1, IGFBP-3, Weight, and Waist Circumference by Treatment Group (Intent-To-Treat Population with Last Observation Carried Forward) At Week 26, treatment with a 2 mg dose of EGRIFTA (1 mg/vial formulation) resulted in a reduction from baseline in mean trunk fat of 1.0 kg in Study 1 and 0.8 kg in Study 2, respectively (compared with an increase of 0.4 kg in Study 1 and of 0.2 kg in Study 2, respectively, in patients receiving placebo)

Do not use in pregnant, lactating women and children under 18 years of age

Studies have shown the positive effects of using DNMT inhibitors, HDAC inhibitors, and extracellular vesicles loaded with miRNAs in preventing mutant huntingtin-induced neurotoxicity, emphasizing the potential roles of epigenetic dysregulations in HD