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Common adverse events include arthralgia (joint pain), myalgia (muscle pain), paresthesia (numbness/tingling), and injection-site reactions like redness

Alternatively, continuous daily dosing for 12 weeks followed by a 4-week break is another common approach

Moreover, HO-1 may attenuate vascular inflammation by reducing VCAM levels, apoptotic factors, release of inflammatory mediators from mast cells and upregulating anti-apoptotic factors (Takamiya et al., 2002