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Given that d-lactate participates primarily via non-enzymatic routes while l-lactate relies on enzymatic transfer (4,112), precise experimental designs are required to dissect the specific contributions of lactyl-CoA-dependent vs

This is why precursors like levodopa are used which can cross the BBB and are metabolized and converted into dopamine in the brain

The possibility that the developed transporter-utilizing (pro)drugs and nanocarriers can interfere with the homeostasis of endogenous substrates of the transporters should be investigated to address safety issues

[DOI] [PubMed] [Google Scholar] 127.Izaguirry A.P., Soares M.B., Vargas L.M., Spiazzi C.C., Dos S.B.D., Noremberg S., Mendez A.S., Santos F.W