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doi: 10.3233/JAD-171153

The enzyme consumes both nicotinamide and S-adenosylmethionine (SAM, the universal methyl donor), potentially affecting both NAD+ metabolism and cellular methylation capacity

The CREM-IbC-X transgenic (CREM-Tg) mice, which exhibit significant age-dependent progressive atrial remodeling and spontaneous AF, provide a useful experimental model to study the role of fibrosis in AF