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Results FoB and MZB exhibit distinct glutathione-based redox dependencies To dissect the redox state of MZB and FoB in relation to the main antioxidant GSH, we studied the expression of Gclc , which is necessary for GSH synthesis 24 , in isolated MZB and FoB from spleens of C57BL/6J (B6 or wild-type) mice

Renal fibrosis, characterized by tubulointerstitial fibrosis and glomerulosclerosis, is the typical outcome of CKD, and represents a growing public health burden and is the leading cause of ESRD [4, 5]

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Carcinoma cells, for instance, form colonies in 3D gels, whereas immortalized NIH-3T3 fibroblasts do not [26, 27]