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The other non-canonical effects of the v-ATPase that are not readily attributable to its proton-pumping activity include membrane fusion, pH sensing, amino-acid-induced activation of mTORC1, and scaffolding for protein-protein interaction 42,54

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DSIP tended to decrease awakenings, enhance sleep efficiency, reduce light sleep stages, and possibly increase REM sleep

Haque SM, Rahman H, Rahman N, Azmi SN, Ashwaq O, Wabaidur SM, Siddiqui MR, Alam M (2023) Application of Box-Behnken design combined response surface methodology to optimize HPLC and spectrophotometric techniques for quantifying febuxostat in pharmaceutical formulations and spiked wastewater samples