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Activation of TRPV1 restored GPX4 levels, reduced lipid peroxidation, and improved cartilage integrity in both IL-1treated chondrocytes and OA mouse models ( These findings highlight the importance of considering cellular heterogeneity in ferroptosis regulation and suggest that targeting ferroptosis in a subpopulation-specific manner may enhance therapeutic precision in OA

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Indeed, ME/CFS may be variably described as encephalopathy, myopathy, dysautonomia, mitochondriopathy, vasculopathy or immunopathy posing the question how all these pathies fit together and which ones are upstream or downstream

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