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10.1016/j.ajpath.2017.11.005 140

HIF-1 and HIF-2 differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice

Studies have shown that IGF-l and IGF1R mRNA expression in cultured young intervertebral disc cells is higher than that in mature cells, and the decrease of IGF-l dependent protein polysaccharide synthesis in rat NPCs is due to the downregulation of IGF-IR in late senescence (Osada et al., 1996

Their crystallographic analysis of the mammalian GIRK2 channel at a resolution of 3.5 also demonstrated the stabilization of four G subunits at the interfaces between the four K + channel subunits (Figure 3)