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This causes the movement of facial fat, leading to the emergence of deep folds in the aged face, which generates heterogeneous creases and depressions [3]

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Red wine contains resveratrol and various flavonoids, which have been associated with cardiovascular health benefits (5153)

Oral brownish pigmentation has also been reported in human immunodeficiency virus (HIV)-positive patients receiving treatment with zidovudine (AZT), ketoconazole and clofazamine (29)