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This remarkable selectivity stems from 5-amino-1MQs specific interaction with the nicotinamide-binding pocket of NNMT, rather than the SAM-binding site common to many methyltransferases

The potential gastrointestinal side effects of these drugs can also further limit food intake, Stanford said, which can "lead patients to avoid certain foods, sometimes worsening nutritional gaps." Therefore, while GLP-1 medication is known for being highly effective, experts warn patients need to ensure they are paying close attention to their dietary needs and wider health while using the drugs

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