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Furthermore, pharmacogenomics accounts for only 20%30% of the causes of inter-individual differences in drug response, with the remaining 70%80% attributable to environmental factors (Lauschke et al., 2024)

350 Mitochondrial dysfunction in Schwann cells triggers alterations in lipid metabolism, leading to myelin sheath dysfunction and accumulation of toxic lipid intermediates, which cause axonal degeneration and neuropathy

After homogenization, the mixture was centrifuged at 1500 rpm for 10 min at 4 C, separating the tissue, which was subsequently utilized for both RNA and protein extraction