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Int J Mol Sci 2007;9:950-988
BMC Psychiatry 8(4):9 Amiri S, Mohammadi MR, Mohammadi M, Nouroozinejad GH, Kahbazi M, Akhondzadeh S (2008) Modafinil as a treatment for attention-deficit/hyperactivity disorder in children and adolescents: a double blind, randomized clinical trial
We found that dietary Met supplementation significantly decreased the relative mRNA expression levels of Nrf2 and NF-B as well as the phosphorylation level of NF-B, increased the levels of downstream antioxidant enzymes HO-1 and NQO-1 in the hippocampi, normalized the levels of inflammatory cytokines in the plasma and hippocampi (IL-1, IL-6, TNF-, and IL-10), and further decreased the expression levels of apoptosis-related genes, including Caspase 3 and Bax (Figs