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These observations underscore an important therapeutic implication for MASLD, showing that the timing and disease stage may be critical for maximizing the protective effects of GSH depletion, with the greatest benefit likely occurring during early, lipogenesis-driven phases of MASLD progression

In the LAT1 inhibition experiments, cells were pretreated with BCH at 5 mM for 2 h, and then incubated with LAAM GSH-CQDs

Lipid Peroxidation