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Inhibition of KEAP1 by RTA 408 disinhibits the antioxidant transcription factor nrf2 and has neuroprotective and seizure reducing effects in the kainic model of TLE (Shekh-Ahmad et al., 2018)

Abbreviations 5-HT: 5-Hydroxytryptophan 5-HT 1A : 5-Hydroxytryptophan receptor 1A -actin: Beta-actin -catenin: Beta-catenin DG: Dentate gyrus DMSO: Dimethyl sulfoxide FM: Fibromyalgia FST: Forced swim test GSK-3: Glycogen synthase kinase 3-beta HDAC: Histone deacetylases HPWL: Hind paw withdrawal latency Miln: Milnacipran PWL: Paw withdrawal latency PBS: Phosphate-buffered saline Res: Reserpine RIF: Reserpine-induced fibromyalgia RIPA: Radioimmunoprecipitation assay RRFOL: Average rotarod fall-off latency SNRI: Serotonin and nor-epinephrine reuptake inhibitor TBST: Tris-buffered saline with Tween 20 TCF: T cell factor TCF/LEF: T cell factor/lymphoid enhancer-binding factor Van: Vanillin Wnt: Wingless-related integration site References Badaeva A, Danilov A, Kosareva A et al (2024) Neuronutritional approach to fibromyalgia management: a narrative review

doi: 10.1038/s42003-023-04959-z 38 DingMLuYHuangXXingCHouSWangDet al