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10.1016/j.jacc.2017.01.064 29 RothG

A summary of the different treatment options, divided across pharmacological and non-pharmacological treatments, can be found in Table 1

Aptamer modification strategies, such as chemical modifications (e.g., LNAs or 2-fluoropyrimidine modifications) and the addition of PEG moieties, have been explored to improve their binding affinity and specificity [132, 135]